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Transcranial Magnetic Stimulation and Bulimic Craving

Transcranial Magnetic Stimulation, Embodied Cognition and Bulimic Craving

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02547246
Enrollment
30
Registered
2015-09-11
Start date
2012-01-31
Completion date
2014-07-31
Last updated
2016-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bulimia

Keywords

bulimia, repetitive transcranial magnetic stimulation (rTMS)

Brief summary

Bulimic patients suffering from binge eating or craving a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories. In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time. Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.

Detailed description

The exams / treatments of the study include: * a 20 minute session of rTMS at a frequency of 10 Hz. * cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rTMS. Cognitive test consist in , on a computer screen: * Is first displayed, food and non-food words. The patient must pull a lever to it if the letter A is present in the word and push the lever if the letter A is missing the word. * Then presents a series of food and non-food words. The patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning

Interventions

One session of rTMS at a frequency of 10 Hz during 20 minutes

DEVICErTMS Placebo (SHAM)

One session of placebo (SHAM) rTMS during 20 minutes

Sponsors

Centre Hospitalier Universitaire de Saint Etienne
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No

Inclusion criteria

* right-handed patient * Patients without psychotropic treatment or treatment with a stable and unchanged for over a month. * Normal BMI

Exclusion criteria

* Previous history of seizures or epilepsy. * Participants with a somatic problem restricted movement or an uncorrected visual acuity problem. * History of head trauma, neurological disease or unstabilized serious physical illness. * Major Depressive Episode at the time of the study

Design outcomes

Primary

MeasureTime frameDescription
Motor response time24h after rTMS sessiontime taken to pull or push the lever in cognitive tests (composite measure)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026