Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone

Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone: Evaluation Using Micro CT 3D High Resolution and by Magnetic Resonance Imaging (MRI)

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02544386

Enrollment

Registered

2015-09-09

Start date

2009-06-30

Completion date

2013-09-30

Last updated

2015-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemiplegia, Stroke

Keywords

bone microarchitecture, hemiplegia

Brief summary

In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow. Rare studies have shown the relationship between some micro-architectural parameters and severity of neurological deficit. There is no study in humans on the evolution of the parameters of the microarchitecture assessed by 3D micro-tomography in the early phase of the installation of neurological deficits after stroke, in terms of a bearing bone, tibia, that a non-load bearing bones, radius.

Detailed description

Each patient must answer several questionnaires about their calcium intake and its ability to perform everyday tasks. They will also have 3 blood samples (15 ml each time), 3 measure of bone by 3D micro-tomography and 2 MRI examination. These examinations and sampling will take place after 30 days after stroke onset (except for MRI) and again after three months and six months after the stroke (the same day as the medical follow-up visit).

Interventions

PROCEDUREMRI and 3D CT scan

Measurement of bone microarchitecture at the legs and wrists by 3D CT Scan and measuring the proportion of fat in the imaging leg bone (MRI)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* at least 30 years * vascular hemiplegia * National Institute of Health Stroke Score equal 4 or greater with a motor of upper limb score greater than or equal 2 and a motor score of greater than or equal legs 2

Exclusion criteria

* Concomitant bone disease * Endocrinopathies * Phasic disorders understanding * Contra-indication to MRI

Design outcomes

Primary

Measure	Time frame	Description
Bone volume / tissue volume	90 days	Measure of Bone volume / tissue volume by the 3D CT scan

Secondary

Measure	Time frame	Description
Bone volume / tissue volume	1 day	Measure of Bone volume / tissue volume by the 3D CT scan
intraosseous fat	90 days	Measure the percentage of the intraosseous fat by MRI

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026