Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia

Efficacy of Granulocyte Transfusions for the Treatment of Severe Infections in Hematological Patients With Febrile Neutropenia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02544230

Enrollment

101

Registered

2015-09-09

Start date

2004-01-31

Completion date

2011-12-31

Last updated

2015-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Infection, Fever, Fever of Unknown Origin, Fungal Infection, Hematological Neoplasms, Neutropenia, Sepsis

Keywords

granulocyte transfusions

Brief summary

The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* fever; * presence of absolute neutrophil count \<0.5 x 10\^9/L * evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences) * unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame	Description
Infection-related mortality	within 30 days after the last granulocyte transfusion	deaths due to infection occurred within 30 days after the last granulocyte transfusion

Countries

Italy

Outcome results