Azoospermia
Conditions
Keywords
azoospermia nonobstructive, male infertility
Brief summary
Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA. It was generally believed that gonadotrophin treatment would be ineffective in the presence of high plasma levels of endogenous gonadotrophin.The purpose of this study is to determine whether GnRHa(gonadotropin-releasing hormone agonist) combined with hCG(human chorionic gonadotropin) and hMG(human menopausal gonadotropin) are effective in the treatment of non-obstructive azoospermia.
Interventions
DRUGGnRHa/ hCG/ hMG
GnRHa was injected subcutaneously at a dose of 3.6mg every 28 days for 5 months. After 2 months from the first GnRHa injection, all subjects were treated with hCG at a dose of 2000 IU once a week for 3 months. After 3 months from the first Goserelin injection, all subjects were treated with hMG at a dose of 150 IU every 3 days for 2 months.
Sponsors
Jinling Hospital, China
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Male subjects aged 18-45 with clinical diagnosis of non-obstructive azoospermia. * At least testicular volume more than 8.0ml on one side . * FSH more than 5.5 IU/L.
Exclusion criteria
* Subjects with anatomical abnormalities of the genital tract. * allergy to the drugs used for treatment. * Y chromosome deletions or abnormal karyotypes. * Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm retrieval rate (SRR) | 4 months | Semen analysis was performed every month from the end of the 6th month (two months after the last injection of hMG) to the end of 9th month until any sperm was found in the semen. If not sperm was found at the end of the 9th month, testicular sperm aspiration(TESA) was performed and the tissue was used for histological assessment. If any sperm was found in the semen analysis or TESA, the treatment was effective. The sperm retrieval rate was calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hormonal profile | 9 months | Serum FSH, LH, Total Testosterone, inhibin B were measured before the treatment and every month after treatment. |
Countries
China
Contacts
Primary ContactBing Yao, MD
Outcome results
None listed