Usefulness of Chromoendoscopy for the Early Detection of Colorectal Cancer Associated With Inflammatory Bowel Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02543762

Acronym

Enrollment

350

Registered

2015-09-07

Start date

2012-02-29

Completion date

2015-05-31

Last updated

2015-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease, Colorectal Cancer

Keywords

Chromoendoscopy, Ulcerative Colitis, Crohn disease, Colorectal Neoplasia

Brief summary

To assess the feasibility and effectiveness of a program in L-IBD patients using CE targeted biopsies

Detailed description

We aim to know the prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (N-IBD), in Spain and the usefulness of advanced endoscopy (chromoendoscopy) for the diagnosis and endoscopic differential diagnosis of N-IBD.

Interventions

PROCEDUREChromoendoscopy

Chromoendoscopy involves the topical application of stains to improve tissue localization and characterization of lessions during endoscopy . Chromoendoscopy has been used in patients undergoing colonoscopy, including those undergoing surveillance for chronic ulcerative colitis. Using pit pattern classifications, chromoendoscopy has a high sensitivity and specificity for differentiating neoplastic from non-neoplastic lesions

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of UC or colitis EC corroborated by clinical and histology * involvement of at least one third of the colon in patients with CD * involvement proximal to the rectum in patients with UC * Duration of disease \> 10 years * No clinical activity: * May Score \<6 * CDEIS \<3.5

Exclusion criteria

* Personal history of CRC * colectomy * coagulopathy * refusal to participate in the study * known allergy to indigo carmine * colonoscopy in the last 6 months

Design outcomes

Primary

Measure	Time frame	Description
Prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (N-IBD), in Spain	two year	see title

Secondary

Measure	Time frame	Description
Usefulness of advanced endoscopy in displasia characterization (chromoendoscopy ) for the diagnosis and endoscopic differential diagnosis of NIBD.	two year	see title

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026