Post-prandial Glucose and Insulin Levels in Type 2 Diabetes Mellitus Patients After Consumption of Ready-to-eat Mixed Meals

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02543684

Enrollment

Registered

2015-09-07

Start date

2013-11-30

Completion date

Unknown

Last updated

2015-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2

Keywords

glycemic response, diabetes, insulinemic response, mixed meals, glycemic index

Brief summary

The aim of the current study was to compare the effects of three ready-to-eat mixed meals, with a high fiber content and low glycemic index, on postprandial glycemic and insulinemic response in patients with Type 2 diabetes mellitus (T2DM).

Detailed description

The current study followed a prospective, three-way, cross-over design. Twenty four patients with T2DM consumed three ready-to-eat mixed meals, i.e. wild greens pie (meal 1), chicken burgers with boiled vegetables (meal 2) and vegetable moussaka (meal 3) and an oral glucose load, all providing 50g of carbohydrates. Venous blood was collected at 0, 30, 60, 90 and 120 minutes postprandial for serum glucose and insulin measurements. The test meals were consumed by study participants between 8:30 to 9:00 am and within 10-15 minutes under a researcher's supervision, following collection of the fasting blood sample. No parallel fluid intake was allowed. The portion size in the case of each one of the three test meals was adjusted to contain 50g of carbohydrates. However, the three test meals were considerably differentiating among them with respect to their content in calories and the remaining macronutrients.

Interventions

OTHERready to eat mixed meal 1

wild greens pie providing 50g of carbohydrates

OTHERready to eat mixed meal 2

chicken burgers with boiled broccoli and cauliflower providing 50g of carbohydrates

OTHERready to eat mixed meal 3

vegetable moussaka providing 50g of carbohydrates

OTHERoral glucose load

glucose load providing 50g of carbohydrates

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

45 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Subjects are eligible if they are 45-75 years of age * non-insulin-dependent T2DM with an elapsed time since diagnosis of more than 3 years * Body Mass Index (BMI) value higher than 20 kg/m2 * HbA1c levels of 6.5 to 11%

Exclusion criteria

* insulin-dependent T2DM * cardiovascular (i.e. coronary heart disease, stroke etc.) * liver and/or renal disease

Design outcomes

Primary

Measure	Time frame
serum glucose changes over time	fasting baseline glucose at time 0, then 30, 60, 90, and 120 minutes postprandial
serum insulin changes over time	fasting baseline insulin at time 0, then 30, 60, 90, and 120 minutes postprandial

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026