Pulmonary Disease, Chronic Obstructive
Conditions
Keywords
Pulmonary Rehabilitation, 3-minute constant rate shuttle walk test, 3-minute constant rate step test, Dyspnea
Brief summary
This is a multi-site collaborative study that will be done in the context of three Quebec hospitals' outpatient pulmonary rehabilitation programs: Montreal Chest Institute; University of Laval, and Hopital Sacre-Coeur Montreal. The objectives are two-fold. First, to determine the Minimal Clinical Important Difference in intensity ratings of perceived breathlessness for each of the 3-min constant rate shuttle walking (3-MWT) and stair stepping (3-MST) protocols in patients with chronic obstructive pulmonary disease (COPD). Second, to test the hypothesis that both the 3-MWT and 3-MST protocols are able to detect statistically significant and clinically-meaningful improvements in exertional breathlessness following an 7-12 week outpatient rehabilitative exercise training program in COPD.
Interventions
OTHERPulmonary Rehabilitation
Patients will participate in 3 exercise training sessions/wk for a period of 7-12 wks at one of 4 sites in Quebec. Each training session will include 30-45 min of aerobic training (cycling and/or treadmill walking) at a target intensity of 80% of the maximal heart rate achieved during a symptom-limited incremental cycle exercise test performed prior to the pulmonary rehabilitation program; and 20-30 min of strength training exercises.
Sponsors
Mount Sinai Hospital, Montreal
Laval University
McGill University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Male or Female * Ambulatory * Moderate-to-very severe COPD (GOLD Stage 2-4)
Exclusion criteria
* Respiratory exacerbation in the previous 6 weeks * Change in medication dosage/frequency in the previous 6 weeks * Clinical evidence of asthma * Cardiovascular and/or neuromuscular diseases that are unstable and/or that may contribute to exercise limitation * Any other contraindications to exercise training/testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimal clinically important difference (MCID) with regards to the change in breathlessness intensity ratings at the end of each of the 3-MST and 3-MWT. | Baseline and 7 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change (post- minus pre- pulmonary rehab) in dyspnea intensity ratings on the Borg 0-10 ratio category scale | Baseline and 7 weeks | Borg 0-10 category ratio scale |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change (post- minus pre- pulmonary rehab) in lung volumes (TLC, FRC, RV) | Baseline and 7 weeks | expressed in L and as % predicted |
| Change (post- minus pre- pulmonary rehab) in airways resistance (Raw, sRaw) | Baseline and 7 weeks | expressed in L and as % predicted |
| Change (post- minus pre- pulmonary rehab) CCQ | Baseline and 7 weeks | questionnaire |
| Change (post- minus pre- pulmonary rehab) CRQ | Baseline and 7 weeks | questionnaire |
| Change (post- minus pre- pulmonary rehab) IPAQ | Baseline and 7 weeks | questionnaire |
| Change (post- minus pre- pulmonary rehab) BDI/TDI | Baseline and 7 weeks | questionnaire |
| Change (post- minus pre- pulmonary rehab) CAT | Baseline and 7 weeks | questionnaire |
| Change (post- minus pre- pulmonary rehab) in Exercise Endurance Time (EET) to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | Baseline and 7 weeks | EET, in minutes and sec |
| Change (post- minus pre- pulmonary rehab) in peak VO2 to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | Baseline and 7 weeks | in ml/kg/min and as %predicted |
| Change (post- minus pre- pulmonary rehab) in peak Ventilation to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | Baseline and 7 weeks | in L/min, as %predicted and as % of MVV (=FEV1x35) |
| Change (post- minus pre- pulmonary rehab) in the 6-minute walk distance | Baseline and 7 weeks | in m |
| Change (post- minus pre- pulmonary rehab) in body composition assessed by dual-energy X-ray absorptiometry | Baseline and 7 weeks | Lean body mass (g) |
| Change (post- minus pre- pulmonary rehab) in isometric quadriceps peak torque | Baseline and 7 weeks | % predicted |
| Change (post- minus pre- pulmonary rehab) in spirometry (FEV1, FVC, and FEV1/FVC) | Baseline and 7 weeks | expressed in L and as % predicted |
Countries
Canada
Contacts
Primary ContactDennis Jensen, Ph.D.
Outcome results
None listed