Natural Course for Renal Function After Heart Transplantation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02541981

Enrollment

500

Registered

2015-09-04

Start date

2015-09-30

Completion date

2016-07-31

Last updated

2015-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Creatinine Clearance Quantitative Trait Locus

Keywords

Heart transplant, renal insufficiency

Brief summary

The outcome of heart transplantation has improved by years. The renal dysfunction is a major complication after heart transplantation.The natural course of renal function following orthotopic heart transplant is not clear in Taiwan. A retrospective study was conducted on patients who received a heart transplant at National Taiwan University Hospital between 1987 and 2015.

Detailed description

The investigators conducted a retrospective cohort study of patients who received a first heart transplant at the NTUH(Taiwan) between 1987 and 2015 . Clinical data were obtained and a retrospective chart review, and were collected up to 10 years . Data was collected from medical records and the heart transplant electronic database including: demographic parameters such as age and gender; etiology of heart failure; the presence of any of the following comorbidities: history of smoking, diabetes, hypertension, peripheral vascular disease and previous sternotomy; pre-transplant cholesterol levels; the use of any of the following pretransplant hemodynamic support measures:intravenous inotropes, intra-aortic balloon pump and ventricular assist device;creatinine levels; listing status according to the UNOS classification; waiting time; heart ischemic time;immunosuppression drug levels(cyclosporine,prograft or certican) and development of end stage renal disease requiring onset of dialysis therapy. Creatinine levels and GFRwere collected before transplantation and then the closest level to every month after heart transplant. The clinical outcomes of interest analyzed in this study included the development of post-transplant end stage renal disease and death.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

This study included patients with a first HTx performed at NTUH between1987 and 2015. Patients were excluded if their first HTx was a combined transplant involving a KTx, they had renal replacement therapy prior to their HTx.

Design outcomes

Primary

Measure	Time frame	Description
Natural course for renal function (ex blood creatine leveal ,eGFR) after heart transplantation	patients who received a first heart transplant at the NTUH(Taiwan) between 1987 and 2015	the outcome measure is assessed up to 10 years

Countries

Taiwan

Outcome results