Acute Hypercapnic Respiratory Failure
Conditions
Brief summary
Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that targets a preseted tidal volume (VT) by automated adjustment of pressure support, could guarantee the delivered VT over pressure-limited noninvasive ventilation (PL-NIV) with fixed level pressure support. Whether VT-NIV is more effective in improving gas exchange in patients with acute hypercapnic respiratory failure (AHRF) as compared with PL-NIV remains unclear. Our aim was to verify whether in comparison with PL-NIV, use of VT-NIV was more effective in correcting hypercapnia, hence reducing the need for intubation and improving survival in patients with AHRF.
Interventions
DEVICEVolume-targeted noninvasive ventilation
Sponsors
Beijing Chao Yang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute hypercapnic respiratory failure (AHRF) * arterial pH \<7.35 and ≥7.25 * PaCO2 \>45 mmHg
Exclusion criteria
* age \<18 years * excessive amount of respiratory secretions or weak cough * upper airway obstruction * recent oral, facial or cranial trauma or surgery * recent gastric or esophageal surgery * severe metabolic acidosis; severe abdominal distension * cardiac or respiratory arrest * PaO2/FiO2 \<150 mmHg * pneumothorax * severe ventricular arrhythmia or myocardial ischemia * severe hemodynamic instability despite fluid repletion and use of vasoactive agents * active upper gastrointestinal bleeding * lack of cooperation * refusal to receive NIV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The decrease of arterial partial pressure of carbon dioxide (PaCO2) values from baseline to 6 hours after randomization | 6 hours after randomization | PaCO2 value at baseline minus PaCO2 value at 6 hours after randomization |
Countries
China
Outcome results
None listed