Diabetes Mellitus
Conditions
Keywords
Blood glucose, Blood insulin, Humans, Postprandial, Carbohydrate, Protein, Resistant starch, Sugar
Brief summary
The purpose of this study was to determine the effect of changing the amounts of resistant starch, whey protein and sugar on the blood glucose and insulin responses elicited by energy bars. The investigators also compared the glucose and insulin responses to the rates at which the food bars were digested in-vitro (in the test tube). The investigators thought increasing resistant starch and reducing sugar would reduce the glucose and insulin responses, and that adding protein would reduce glucose and increase insulin. The investigators also thought the glucose and insulin responses in people would be related to the rate of digestion of the food bars in-vitro.
Interventions
Sponsors
PepsiCo Global R&D
Glycemic Index Laboratories, Inc
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index 20.0 to 34.9 kg/m² * Fasting serum glucose \<7.0mmol/L * Non-smoker
Exclusion criteria
* Known to have diabetes * Use of medications or presence of a medical condition considered by the principal investigator to increase risk to the participant or affect the results * Known food allergy of any kind
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incremental area under the blood glucose response curve | For 3 hours after consuming each test meal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incremental area under the serum insulin response curve | For 3 hours after consuming each test meal | — |
| Incremental area under the blood glucose response curve | For 2 hours after consuming each test meal | — |
| Insulin:Glucose area under the curve ratio | For 3 hours after consuming each test meal | Outcome 2 (incremental area under the insulin response curve for 3 hours) divided by Outcome 1 (incremental area under the glucose response curve for 3 hours) |
| Insulinogenic index | 30 minutes after consuming each test meal | I30 divided by G30; where I30 is the serum insulin increment at 30 minutes and G30 is the blood glucose increment at 30 minutes; and where increment is defined as the concentration at 30 minutes minus the fasting concentration. |
Countries
Canada
Outcome results
None listed