Lung Cancer, Video-assisted Thoracoscopic Surgery
Conditions
Keywords
dexmedetomidine, quality of recovery
Brief summary
Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).
Interventions
DRUGDexmedetomidine
Formula for administrated were randomized by computer-generated randomization. The patients and anesthesiologist, who administered and conducted all this trial, were blinded to the medication allocation. An anesthesiologist, who responsible for preparation of medication was the only person, recognized of the randomization code during trial. After one-lung ventilation, dexmedetomidine group would start the loading of dexmedetomidine (1μg/kg) during 20 minutes.
DRUGNormal saline
Saline placebo infusion will be adjusted the same fashion as the active comparator drug.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer 2. Adults above 20 years of age and providing informed consent. 3. American Society of Anesthesiologists (ASA) Physical class II, & III patients
Exclusion criteria
1. severe functional liver or kidney disease 2. history of chronic pain requiring opioid treatment 3. arrhythmia or received treatment with antiarrythmic drug . 4. severe bradycardia (HR \< 45 bpm) and AV block 5. pathologic esophageal lesion (esophageal stricture or varix ) 6. pregnancy 7. psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire 8. History of alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| quality of recovery measured by QoR-40 questionnaire | 24 hr after operation | — |
| pulmonary function test | 24 hr after operation | postoperative lung function assessed by spirometry |
Countries
South Korea
Outcome results
None listed