Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02535936

Enrollment

Registered

2015-08-31

Start date

2015-08-31

Completion date

2031-01-01

Last updated

2024-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spastic Diplegia

Keywords

Cerebral Palsy

Brief summary

The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Detailed description

To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.

Interventions

PROCEDURE3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia

2 post-operative MRI's at 2 months and 12 months

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

3 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery

Exclusion criteria

* No Selective Dorsal Rhizotomy surgery

Design outcomes

Primary

Measure	Time frame	Description
Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR).
Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR).
Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)
Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)

Countries

United States

Contacts

Primary ContactManish N Shah, MD

Manish.N.Shah@uth.tmc.edu713 500-7410

Backup ContactBangning L Yu, RN, PhD

Bangning.Yu@uth.tmc.edu713 500-7363

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026