Cataracts
Conditions
Keywords
Cataract surgery
Brief summary
Cataract is the clouding of the lens of the eye, which initially prevents clear vision and eventually progresses to blindness if left untreated. Cataract remains the leading cause of blindness and an important cause of visual impairment across the globe. Cataract surgery by ultrasonic phacoemulsification is the most common surgery practiced in France (600 000/year) Two sub-categories of phacoemulsification coexist : Endocapsulars techniques represented by Divide-and-Conquer and Phaco-Chop ; and Supracapsular techniques mainly represented by Subluxation (similar to Tilt-and-Tumble) The corneal endothelium plays an important role in maintaining the dehydrated state and the transparency of the cornea. Some degree of endothelial cell loss invariably occurs in all types of cataract surgery but the amount of endothelial cell loss may varies with the type of surgical technique The aim of the study is to evaluate the density of the central corneal endothelial cells before and after cataract surgery comparing two phacoemulsification techniques (Divide-and-Conquer vs Subluxation)
Interventions
PROCEDURESubluxation
One pole of The nucleus is hydrodissected until it lilts above the capsular bag. The tilted nucleus is rotated to face the incision and remaining half nucleus is then tumbled and emulsification continues from the opposite equator outside in until complete
PROCEDUREDivide and Conquer
Cataract nucleus is fragmented into 4 pieces then aspirated by ultrasonic vibration
Sponsors
Centre Hospitalier Régional Metz-Thionville
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female aged ≥ 18 years * Patients undergoing cataract surgery * Visual acuity Monoyer scale \<6/10e (\< +0.2 logMar) * Nuclear, cortical and posterior subcapsular cataract with normal density to severe in the LOCSIII classification
Exclusion criteria
* insulin-dependent diabetes and /or diabetic retinopathy * corneal disease: keratitis, dystrophy, corneal degeneration * Any disease of intraocular pressure * Any disease of the anterior segment * Low preoperative endothelial cell density \< 1500 c/mm² * Combined surgery (cataract + corneal transplant, cataract + glaucoma surgery, cataract +vitrectomy ...) * Risk factors for surgical per-operative complication * Pregnancy, lactation * Ward of court * Patient not covered by the Social Security scheme
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Outcome Measures: postoperative Endothelial cell loss of the central corneal | 12 month |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORJean-Marc PERONE, MD
CHR Metz-Thionville
Outcome results
None listed