Clinical Symptoms, Drosophila
Conditions
Brief summary
Allergy is a very common problem and can be a handicap in everyday life, specially when symptoms occur at work place. Some persons working with drosophila developed respiratory symptoms. Investigators tried to analyze if these manifestations could be due to a specific allergy to drosophila.
Detailed description
To do so, investigators invited laboratory workers who presented any symptoms in presence of drosophila to undergo skin prick tests in order to determine if a specific sensibilization to drosophila exists. Then, a blood sample is taken from these persons to research specific IgE directed against drosophila. By this way, investigators hope determine if a specific allergy to drosophila exists, its characteristics as prevalence, symptoms, populations concerned...in order to better protect laboratory workers and prevent allergy incidence.
Interventions
OTHERblood test (four dry tubes 7ml) and prick tests
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 68 Years
Healthy volunteers
No
Inclusion criteria
* major males or females (aged \<68) who work in laboratory with drosophila in Montpellier (France) * clinical symptoms in presence of drosophila * The subject must be affiliated to a social security scheme * Provision of informed consent prior to any study specific procedures
Exclusion criteria
* The patient has indicated against (or incompatible drug combination) concerning the implementation of a prick test * antihistamine cure in progress * Inability to understand the nature and goals of the study and / or communication difficulties with the investigator * No affiliation to a French social security recipient or not such a scheme * Major protected by law (guardianship, curator or under judicial protection) * deprivation of liberty by judicial or administrative decision * Increased likelihood of non compliance to the protocol or abandonment under study * pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with positive prick test to drosophila | The day of inclusion | Prick tests : measuring the size of the skin reaction (wheal) after prick tests with drosophila. A wheal measuring more than 4 millimeters in diameter sign a sensitization to drosophila. Then, a blood sample is collected in order to measure specific drosophila IgE rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survey to analyse risk factors for allergy to drosophila | The day of inclusion | analysis of professional (attended institute, time from start working with drosophila, type of animal manipulation (species, living, dead, DNA, protein) use of protection,) or personal factors (age, gender, others allergies, treatment used) which could lead to allergic reaction to drosophila |
Countries
France
Outcome results
None listed