Schizotypal Personality Disorder
Conditions
Brief summary
Neurophysiological indices of self-monitoring were assessed in a group of patients with Schizotypal Personality Disorder (SPD) and a control group. Both groups were assessed after the administration of risperidone and placebo.
Detailed description
The electroencephalogram (EEG) was recorder while participants (SPD participants and controls) performed a behavioral task: the Eriksen Flanker Task. The continuous EEG was segmented, corrected for artifacts and averaged. A component of the event-related brain potential known as the error-related negativity (ERN) was identified and its amplitude quantified in microvolts. This procedure was conducted two hours after the administration of risperidone 1 mg and placebo (lactose) on two different experimental days and for each participant group (SPD patients and controls). The amplitude of the ERN after placebo was compared between groups to test for baseline (non-drug-induced) differences between patients and controls. The impact of risperidone on the amplitude of the ERN was compared between the two participant groups.
Interventions
DRUGRisperidone
1 mg Risperidone
DRUGPlacebo
Lactose Placebo
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Schizotypal Personality Disorder
Exclusion criteria
* Major Psychiatric Disorder * Medical condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurophysiological indices of self-monitoring (Error Related Negativity) | During acute effects of pharmacological treatment (up to 2 hours) | Amplitude of the Error Related Negativity was assessed prior to and 2 hours after treatment administration |
Outcome results
None listed