Unilateral Hearing Loss
Conditions
Keywords
single sided deafness., Auditory plasticity, Asymmetrical hearing loss, Cochlear implants, Inter hemispheric asymmetry, Lateralization index, Dichotic hearing
Brief summary
The objective is to study the relation between the reorganization of the central auditory system, and the psychophysical deficits in binaural hearing in subjects with single sided deafness.
Detailed description
Background Single sided deafness (SSD) and asymmetrical hearing loss are common hearing impairments, and their social consequences are well established. At the central auditory system level, the single sided deafness is associated with a reorganization of auditory temporal cortices that leads to a reduction of inter hemispheric asymmetry. Purpose : Our main objective is to study the relation between the reorganization of the central auditory system, namely the inter hemispheric asymmetry, and the psychophysical deficits in binaural hearing in subjects with SSD. Abstract : Binaural hearing enables spatial localization of the sound source and improves speech recognition in a competing noise. SSD and asymmetrical hearing loss are common hearing impairments, which affect 0.3 to 1/1000 children. In the adult population, this prevalence increases with age. The impact of SSD and asymmetrical hearing loss on quality of life indices is well established and some reports underline its consequences in children scholarship. Previous neuro-imaging and electro physiological studies highlighted the reduction of normal inter hemispheric asymmetry in subjects with SSD. To the best of our knowledge, there is no report about the relation between the central auditory system reorganization and its behavioural deficits. The investigators propose to conduct a study which analyzes the relationship between the reduction of inter hemispheric asymmetry and performance in binaural hearing tests. Thus, the auditory plasticity will be studied using functional magnetic resonance imaging and more specifically BOLD variations in auditory temporal cortices. A set of binaural hearing assessments will be performed, including speech recognition in noise and localization abilities. The correlation between the lateralization ratio and binaural measurements (speech reception threshold (SRT) in dichotic hearing, diotic hearing, reverse dichotic hearing) will be estimated. Likewise, the impact of SSD duration on cortical reorganization and binaural tests will be studied.
Interventions
OTHERfunctional magnetic resonance imaging
functional magnetic resonance imaging
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Right-handed subjects * SSD confirmed using evoked auditory potentials
Exclusion criteria
* Associated neurological disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lateralization index | 4 weeks | ratio of the BOLD signal (blood oxygenation level dependent) obtained at the superior temporal cortex in response to stimulation of the monaural sound to the ear BOLD signal obtained for the same stimulus presented binaurally |
| Speech Reception Threshold | 4 weeks | signal / noise ratio for the recognition of 50% of the words in dichotic hearing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SRT in reverse dichotic hearing, mean localization error angle | 4 weeks | — |
| the percentage of errors in test horizontal location of the sound source | 4 weeks | — |
| seniority of deafness | inclusion | requested information to the patient OR recovered in his medical file |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMathieu Marx, MD
University Hospital of Toulouse
Outcome results
None listed