Ischemic Stroke
Conditions
Brief summary
A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.
Detailed description
Ischemic stroke patients who are 8-24 hrs from symptom onset without prior mechanical or IV thrombolytic treatment and are screen with CT or MR perfusion imaging showing penumbra and infarction not \> 1/3rd the territory.
Interventions
DEVICEmechanical thrombectomy
Mechanical thrombectomy by either Penumbra system, TREVO, or Solitaire retrieval device
Sponsors
Abington Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
with control group
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Over 18 years last seen normal between 8 - 24 hours, without prior history of intravenous plasminogen activator (IV t-PA ) or * mechanical thrombectomy Vessels - intracranial vertebral artery, basilar artery, intracranial ICA, ICA terminus bifurcation, MCA M1/M2, or * ACA NIHSS ≥ 7 MRI DWI/PWI or * CTA/P, which demonstrates an area of mismatch ≥ 2/3 rd * Signed informed consent
Exclusion criteria
* creat \>= 2 * NIHSS \< 7 * Baseline mRS \>= 2 * infarct \> 1/3rd MCA territory * competing trials * prior IV or IA treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombolysis in Cerebral Infarction (TICI) score | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale (NIHSS) score | 6 months |
| Montreal Cognitive Assessment (MoCA) tool | 6 months |
| Modified Rankin Scale | 6 months |
Countries
United States
Outcome results
None listed