Lung Cancer
Conditions
Brief summary
Diagnose lung cancer at an early stage is crucial for effective treatment. At these early stages, cancer is usually invisible in ambient white light when the endoscopic analysis of the bronchial mucosa. This lining is self-fluorescent at its illumination by blue light. These widely distributed autofluorescence methods detect early mucosal abnormalities. They are very sensitive but not specific to recognize the lung cancer. Thanks to European funding (EURIMUS), a new tool with fluorescent UV light has been developed. The purpose of this preliminary study is to verify the suitability for specific detection of cancerous tissue in Pneumology of this fluorescence method versus histological analysis of the tissue.
Interventions
PROCEDURERigid bronchoscopy with ultraviolet transmission
OTHERBiopsy
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient affiliated or entitled to a social security scheme * Major Patient * Patient who signed the informed consent document * Patient with a known primary cancer in bronchial level
Exclusion criteria
* Pregnant woman * Patient with a benign tumor histology * Patient with an unknown tumor histology.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ultraviolet fluorescence ratio Iodine360 / Iodine450 | Day 0 | Detection of cancerous tissues and healthy or inflammatory tissues is used to calculate the sensitivity and specificity of the rigid bronchoscopy with UV transmission compared to biopsy (gold standard). |
| Histology of tissue | Day 0 | The histology give the final diagnosis |
Countries
France
Outcome results
None listed