Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus

Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus. Diagnostic Value of White Light Endoscopy, Narrow Band Imaging and Chromoendoscopy for Detection of Esophageal Manifestation in Patients With Oral Lichen.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02532166

Enrollment

Registered

2015-08-25

Start date

2012-01-31

Completion date

2016-12-31

Last updated

2015-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lichen Planus

Keywords

narrow band imaging, Chromoendoscopy, Lugol

Brief summary

The lichen planus is a mucocutaneous disease of unknown etiology with an incidence of 1-2%, that affects in 30-70% of cases either the mucosa of the mouth, or partly in combination with infection of the skin, the oral with his known premalignant potential in up to 2-3% predisposed to the development of an oral squamous cell carcinoma.In rare cases, there is also an manifestation of the lining of the esophagus, which can then be associated with symptomatic strictures of the esophagus. The value of moreover increasingly established endoscopic imaging procedures are investigated as well as data of the natural long-term outcome in esophageal lichen planus infestation especially in view of malignant transformation.

Detailed description

The lichen planus is a mucocutaneous disease of unknown etiology that manifests itself with an incidence of 1-2% in 30-70% of cases either at the mucosa of the mouth, or partly in combination with infection of the skin, the oral with his known premalignant potential in up to 2-3% predisposed to the development of an oral squamous cell carcinoma. In rare cases, there is also an manifestation of the lining of the esophagus, which can then be associated with symptomatic strictures of the esophagus. In addition, four cases have been reported with esophageal squamous cell carcinoma in patients with esophageal lichen planus. The value of moreover increasingly established use of narrow-band imaging (a process for improving the detection of early cancers in the gastrointestinal tract by creating a maximum contrast between outright and altered mucosa, which could have already shown an improved detection rate of early lesions of the esophagus as well as squamous cell carcinoma), or the chromoendoscopy has means for example Lugol solution in correlation to the histopathologic findings in lichen planus), has not been investigated to date. Also, data of the natural long-term outcome in esophageal lichen planus infestation especially in view of malignant transformation are currently not available.

Interventions

OTHEREsophageal lichen planus

White light endoscopy compared to narrow band imaging and Lugol for detection of esophageal lichen.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years * Known lichen planus of the oral mucosa

Exclusion criteria

* Severe cardiopulmonary disease - ASA (American Society of Anaesthesiology) class \> III * Antisecretory and nonsteroidal anti-inflammatory medication within the last month

Design outcomes

Primary

Measure	Time frame
Value of additional endoscopic enhancing imaging methods for detection of esophageal lichen planus.	3-5 years

Secondary

Measure	Time frame
Natural long-term incidence of esophageal lichen planus in patients with known oral lichen.	3-5

Countries

Germany

Contacts

Primary ContactAndrea Riphaus, PD MD

ariphaus@web.de0049 511 8208

Backup ContactPohl Michael, MF

Michael.pohl@rub.de0049 0234 299

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026