Healthy
Conditions
Keywords
healthy volunteers
Brief summary
Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.
Detailed description
Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.
Interventions
DEVICElaser stimulations on lower limbs
20 laser stimulations for each site : back foot, outer face of the legs, and anterior thigh
DEVICElaser stimulations cervical
15 laser stimulations cervical areas below the ears.
DEVICE20 laser stimulations for each site on the upper limbs
20 laser stimulations for each site : back of the hands and arms front face
DEVICElaser stimulations on face and neck
15 lasers stimulations for each site : mandibular areas and areas below the ears.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* major
Exclusion criteria
* Neurological history * Neuralgia history (\> 3 months) * Pathology can cause neuropathy (unbalanced thyroid dysfunction, diabetes, kidney failure, chronic hepatitis, HIV ...) * Dermatological disorder known type of Lucite or photosensitivity * Medical treatment analgesic, psychotropic or anti-epileptic underway * Toxic acquired in the last 72 hours (alcohol, cannabis, other toxic ...) * Pregnant women * Incapacitate to stand still * Participation in another biomedical research in the field of pain in the three months prior to inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential | Day 0 |
Secondary
| Measure | Time frame |
|---|---|
| detection threshold (mJ/mm2) | Day 0 |
| nociceptive threshold (mJ/mm2) | day 0 |
Countries
France
Outcome results
None listed