Meniere's Disease
Conditions
Brief summary
* This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in patient's with Meniere's disease. * MR Perfusion Imaging will be assess in both cochlea as well * Primary auditory brain pathways will be evaluated through MR diffusion imaging
Interventions
DRUGGadolinium
diffusion of gadolinium for a population with Meniere's disease in order to develop an imaging disease screening test
Sponsors
Guerbet
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years) * Informed consent signed * Medical examination performed prior to participation in research * Patients with clinical criteria of Meniere's disease according to the classification of the American Association of Otology (ie the combination of a sensorineural hearing loss at low frequencies, recurrent vertigo and tinnitus and / or clogged ear sensation) * Recipient of a French social security scheme
Exclusion criteria
* Patients minors * Patients on a legal protection regime type guardianship * Respiratory pathologies, cardiovascular, renal, diabetes * Claustrophobia * Contraindications to exposure to a magnetic field * Contraindications to injecting Dotarem ®
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gadolinium enhancement in inner ear structures as measured by MR T1 Weighted-Imaging dynamic measurement | One MR scan (4 hours) |
Countries
France
Outcome results
None listed