HIV/AIDS, HIV Lipodystrophy Syndrome
Conditions
Keywords
energy expenditure, doubly labeled water, accelerometer, HIV, lipodystrophy syndrome.
Brief summary
Background: Several studies have reported increased resting energy expenditure (REE) in people living with HIV/AIDS possibly due to changes in body composition that occurs in HIV lipodystrophy syndrome. The aim of this study was to evaluate the influence of the use of lipid-lowering drugs in resting energy expenditure (REE) and total energy expenditure (TEE) in patients seropositive for HIV in treatment of lipodystrophy.
Detailed description
REE was measured by indirect calorimetry. TEE was measured by doubly labeled water (DLW) technique and an activity monitor based on accelerometry (AM).
Interventions
DRUGuse of lipid-lowering drugs.
The patients shoud be in use of a lipid-lowering drugs previouly, at least one month before of the begining of the study.
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
University of Sao Paulo General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Use of antiretroviral therapy for at least 4 months * A cluster of differentiation 4 (CD4) T-cell count of \>200 cells/mm3 * Use of lipid-lowering drugs for at least 1 month (group HIV-seropositive with lipodystrophy and use of lipid-lowering)
Exclusion criteria
* Signs or symptoms of opportunistic infections * Thyroid disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Energy Expenditure (kcal/d) | 14 day |
| Resting Energy Expenditure (kcal/d) | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between doubly labeled water and accelerometer to measure total energy expenditure (ICC, 95% CI) | 14 days |
Outcome results
None listed