Inhalation and Intravenous Anesthesia, Microcirculatory Effects of Anesthesia
Conditions
Keywords
microperfusion, temperature, near-infrared spectroscopy, anesthesia, total intravenous anaesthesia
Brief summary
Effects of different general anesthetics on peripheral microcirculation.
Detailed description
Human keep body temperature in a narrow range by a variety of regulatory mechanism. Peripheral thermal receptors send signals to central nervous system which regulate body temperature via peripheral effectors, such as vasoconstriction, vasodilatation, shivering, sweating and etc. In patients undergoing general anesthesia, the regulatory mechanism is altered. General anesthesia changes blood distribution in the body, the metabolic rate of muscle, threshold of thermal regulation in the brain and etc, so that heat distribution and microcirculation condition will also change. In this study, near-infrared spectroscopy (NIRS) is used to measure the microcirculatory condition. NIRS is a non-invasive continuous measurement to detect tissue saturation with the method of different wavelength of near-infrared. General anesthesia with inhalational sevoflurane and intravenous propofol is separated into 2 groups. Because of different mechanism of general anesthesia of these 2 anesthetics, different physiologic response may occur. Body temperature and somatic saturation are compared in each group.
Interventions
DRUGPropofol
General anesthesia maintained with intravenous propofol infusion
DRUGSevoflurane
General anesthesia maintained with inhalational sevoflurane
PROCEDUREGeneral anesthesia induction
Induce routine of general anesthesia, including propofol 1-3mg/kg, fentanyl 1-3mcg/kg, cisatracurium 0.2-0.3mg/kg.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Breast surgeries under general anesthesia 2. BMI 18.5\ 30
Exclusion criteria
1. Cardiac disease 2. Lung disease 3. Renal disease 4. Neurological disease 5. Autonomic nervous system dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Somatic saturation | during surgery, approximately 2-4 hr | Change of somatic saturation measured by NIRS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body temperature | during surgery, approximately 2-4 hr | Nasal and peripheral temperature |
Countries
Taiwan
Contacts
Primary ContactCheng-Han Yen
Backup ContactCheng-Han Yen
Outcome results
None listed