Dyslipidemia
Conditions
Brief summary
The purpose of this study is to see if a high-protein meal leads to a better postprandial (after a meal) blood lipid profile compared to a high-monounsaturated meal.
Detailed description
The effect of a high-protein diet compared to a high-monounsaturated fat diet on fasting lipids is controversial (1,2), In addition, these studies did not examine the effect of a high-protein compared to a high-monounsaturated meal on postprandial lipid concentrations. Postprandial lipid responses are important to examine since they are associated with heart disease (3,4). In addition, most individuals in Western countries are in a postprandial state for majority of the day. The present study will compare the effect of a high-protein meal versus a high-monounsaturated fat meal on postprandial lipid responses.
Interventions
OTHERHigh-Protein Condition
The participants will be fed a high-protein meal
OTHERHigh-Monounsaturated Fat Condition
The participants will be fed a high-monounsaturated fat meal
Sponsors
Texas Christian University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women ages 18-65 years.
Exclusion criteria
* Use of medications or supplements that affect lipid levels, body weight, or blood glucose, * following a weight loss diet, * being a vegan, * smoking, * heavy alcohol use, * pregnancy, * lactation, * severe depression, * eating disorders, * presence of liver, kidney, gastrointestinal, adrenal, or untreated thyroid disease, * diabetes, * lactose intolerance, * documented mal-absorption, or * bowel surgery that affects absorption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lipid concentrations. | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
Secondary
| Measure | Time frame |
|---|---|
| TNF-α | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| C-reactive protein | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| GLP-1 | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| IL-6 | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Glucagon | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Glucose | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Leptin | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Insulin | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
Countries
United States
Outcome results
None listed