High Intensity Interval Training and Rheumatoid Arthritis

Conditions

Rheumatoid Arthritis

Keywords

High Intensity Interval Training

Brief summary

The overall objective is to determine whether High Intensity Interval Training (HIIT) has potential to improve disease activity scores for Rheumatoid Arthritis (RA) patients. By reducing inflammation and modifying immune function HIIT may offer a substantial paradigm shift in RA care, especially in older persons with RA who experience aging related-immunesenescence, increased systemic inflammation and greater physical inactivity than young persons. Prior to embarking on a large scale trial of HIIT-induced disease modification, this pilot study aims to demonstrate that HIIT can produce measurable responses in disease activity scores and peak VO2in persons undergoing routine pharmacologic treatment for RA.

Brian J. Andonian, Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal et al. (13 authors)

Scientific Reports2022-05-0619 citations

10.1038/s41598-022-11458-4

Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Brian J. Andonian, Andrew Johannemann, Monica J. Hubal, David Pober, Alec Koss et al. (8 authors)

Arthritis Research & Therapy2021-07-1036 citations

10.1186/s13075-021-02570-3

Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.

Andonian BJ, Bartlett DB, Huebner JL, Willis L, Hoselton A, Kraus VB, Kraus WE, Huffman KM.

2018-12-2717 citations

10.1186/s13075-018-1786-6

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

Bartlett DB, Willis LH, Slentz CA, Hoselton A, Kelly L, Huebner JL, Kraus VB, Moss J, Muehlbauer MJ, Spielmann G, Kraus WE, Lord JM, Huffman KM.

2018-06-14101 citations

10.1186/s13075-018-1624-x

Interventions

BEHAVIORALHIIT

All participants will undergo high intensity interval training 3x/week for 10-12 weeks. Intense exercise will be interspersed with appropriate rest periods of low intensity exercise

Study design

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

No

Inclusion criteria

* Seropositive (positive rheumatoid factor or anti-citrullinated protein antibody) or erosions typical of RA on radiographs. * History of fulfilling 2010 ACR/EULAR Classification Criteria for RA * Able to walk on a treadmill * Not participating in regular physical exercise (more than 60 minutes of moderate intensity or 30 minutes of vigorous intensity exercise per week) or weight reduction dieting. * No medication changes within the last three months. * Willing to forego knee joint injections, regular NSAID use, and use acetaminophen for any necessary analgesia during the course of the intervention. * No current (within the last three weeks) pharmacologic therapy with corticosteroids.

Exclusion criteria

* Coronary artery disease * Diabetes mellitus * Chronic obstructive pulmonary disease * Absolute contra-indications to exercise: Recent (\<6 months) acute cardiac event unstable angina, uncontrolled dysrhythmias causing symptoms or hemodynamic compromise, symptomatic aortic stenosis, uncontrolled symptomatic heart failure, acute pulmonary embolus, acute myocarditis or pericarditis, suspected or known dissecting aneurism and acute systemic infection. * Other inflammatory arthropathy or myopathy, Paget's disease, pigmented villonodular synovitis, joint infection, ochronosis, neuropathic arthropathy, osteochondromatosis, acromegaly, hemochromatosis, Wilson's disease, osteonecrosis, knee replacement. * Contraindicated Medicine: ticlopidine, clopidogrel, dipyridamole, warfarin, heparin, enoxaparin and other blood thinners.

Design outcomes

Primary

Measure	Time frame
Change in Disease Activity Scores	Baseline and Post-Intervention (12-weeks)

Secondary

Measure	Time frame
Change in Peak Oxygen Consumption	Baseline and Post-Intervention (12-weeks)

Countries

United States

Outcome results

None listed