Postoperative Nausea and Vomiting
Conditions
Brief summary
To evaluate the efficacy of pre-empetive administration of Aprepitant, Versus Gabapentin prophylaxis for reducing the incidence of postoperative nausea and vomiting in Laproscopic gynacological surgeries.
Detailed description
Postoperative nausea and vomiting (PONV) is frequently encountered in the surgical recovery room. Laparoscopic surgery is one important risk factor for increased incidence of PONV. Gabapentin, an anticonvulsant with known postoperative analgesic properties, has shown some activity against PONV. Results from clinical trials evaluating the anti-emetic efficacy of gabapentin are conflicting. Aprepitant, a neurokinin-1 (NK1) receptor antagonist, blockades the central effects of substance P. Substance P is a neurotransmitter found in central areas associated with emesis such as the dorsal vagal complex and area postrema.
Interventions
DRUGdexamethasone
dexamethasone 8 mg iv 2 minutes before induction of anesthesia
DRUGGabapentin
oral gabapentin 600 mg 1 hour before induction of anesthesia
DRUGAprepitant
oral aprepitan 80mg 1 hour before induction of anesthesia.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
• ASA physical status I and II aged between 18 and 45 yrs. They undergo Laproscopic gynacological surgeries under general anesthesia.
Exclusion criteria
* Central or peripheral neurological pathologies. * History of drug abuse, chronic pain, or psychiatric disorders. * Pregnant women * Patients who took sedatives, antiemetics, or antipruritics within 24 hrs of operation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence (%) of postoperative nausea and vomiting | 24 hours postoperative | The incidence (%) of PONV will be recorded each 6 hours until 24 hours after discharge from the PACU. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| non invasive blood pressure | intra-operative from induction of general anesthesia till end of surgery. | Noninvasive blood pressure measured immediately after induction of anesthesia ,15 min.30 min.45 min. and 60 min till the end of surgery |
| heart rate | Intra-operative from induction of anesthesia till end of surgery. | heart rate recorded immediately after induction of anesthesia ,15 min.30 min.45 min. and 60 min till the end of surgery |
| side effects | 24 h postoperative. | Side effects of given drugs will be treated and recorded |
Countries
Egypt
Outcome results
None listed