Allergy, Obesity
Conditions
Keywords
arachidonic aci, adiposity, atopy
Brief summary
Epidemiological studies have shown obesity to be a risk factor of asthma. Research evidence of obesity and atopic(ie. allergic)-related respiratory diseases, has been less clear. The purpose of the present study was to test the hypothesis that the relationship between obesity and atopic-related respiratory disease in premenopausal women is mediated by a dietary imbalance of omega 6 and 3 polyunsaturated fatty acids.
Detailed description
Sixty young adult obese and non obese women, with, and without asthma, were studied using a cross-sectional design. Body composition was measured by plethysmography. A fasted blood sample was taken to measure: specific and total immunoglobulin (IgE) antibodies,biochemical markers of atopy; glucose and insulin to measure insulin sensitivity; estrogen(17β-estradiol) and sex hormone-binding globulin to measure estrogen status of the women; hormone-products of fat tissue ( leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukins (IL-6,IL-18), that have been associated with both obesity and immune processes involved in asthma and allergy. Dietary intake of omega 6: linoleic acid (LA), arachidonic acid(AA); and omega 3 fatty acids: α linolenic (ALA), eicosapentanoic (EPA) and docosahexanoic (DHA) and other nutrients were assessed by food frequency questionnaire.
Interventions
None listed
Sponsors
University of New Hampshire
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* For asthmatics, only individuals that were willing and capable of not using asthma medications for two days prior to laboratory testing.
Exclusion criteria
* An individual was excluded from the study if she had a history of high blood pressure, diabetes, heart disease, cigarette smoking, or eating disorders. * Women that were pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictors of serum concentration of specific and total IgE antibodies in obesity | one day | Measures of insulin sensitivity, plasma concentrations of leptin, adiponectin, , estrogen, IL-18,and dietary arachidonic, eicosapentanoic, docosahexanoic fatty acids were entered as independent variables; and serum concentration of specific and total IgE antibodies as dependent variable, in a forward stepwise multivariate linear regression analysis to identify which factor(s) had the greatest influence on serum concentrations of IgE antibodies in obesity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between dietary levels of arachidonic, eicosapentanoic, docosahexanoic fatty acids and plasma concentration of leptin in obesity | one day | Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of leptin in obese and non obese women. |
| Correlation between dietary arachidonic, eicosapentanoic,and docoshexanoic fatty acids and plasma concentration of adiponectin in obesity | one day | Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of adiponectin in obese and non obese women. |
Outcome results
None listed