Cardiac Failure
Conditions
Brief summary
In patients with heart failure, the drive to the effort has demonstrated its safety and its interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial NO synthase. The rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. The impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease. The main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with Tomography Positron Emission 15O-H2O.
Interventions
PROCEDUREcardiac Rehabilitation
OTHERTomography Positron Emission
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with heart failure with nonischemic dilated cardiomyopathy * Class II-III NYHA (New York Heart Association) * Having no contra-indication to the effort * Fraction Ejection ≤ 40% * patient who will have cardiac rehabilitation * Age over 18 years * informed consent signed * patient with a social security scheme
Exclusion criteria
* Hypertension\> 160/90 mmHg * High cholesterol level \> 6.0 mmol / l * Diabetes known and treated * Active smoking * Valvular heart disease, congenital or ischemic * Pregnant or breastfeeding women * Age \<18 years * Major Adult guardianship
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of myocardial blood flow during the cold test | change over baseline and after 3 month |
Countries
France
Outcome results
None listed