Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02523742

Acronym

BIP

Enrollment

152

Registered

2015-08-14

Start date

2005-11-30

Completion date

2015-04-23

Last updated

2020-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropsychiatric Disorders

Brief summary

Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness. Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Interventions

DEVICEIMRf

OTHERlanguage task and a reference task (rest and Tamil)

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* patients under 65 years * Schizophrenics, bipolar or schizoaffective (DSM IV) * Patients who signed informed consent

Exclusion criteria

* Women with childbearing potential without effective contraception or positive pregnancy test. * Contra-indications to fMRI

Design outcomes

Primary

Measure	Time frame
variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest	baseline

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026