Measurement of Glomerular Filtration Rate (GFR) in HIV Patients: Single-center Study Comparing the Accuracy of Estimators of GFR Versus Iohexol Plasma Clearance

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02522338

Acronym

HIVOL

Enrollment

300

Registered

2015-08-13

Start date

2011-02-28

Completion date

2013-12-31

Last updated

2016-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV

Brief summary

Cystatin C, a protease inhibitor produced by most nucleated cells, is freely filtered by the kidneys, and its plasma assay reflects the GFR. Compare, in HIV patients, the predictive performance of 11 formula to estimate GFR based on assay plasma cystatin C with that of the MDRD formulas.

Interventions

DRUGiohexol

10 ml de l'iohexol (300 mgI/ml)

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients infected with HIV, and included in the cohort NADIS

Exclusion criteria

* Patient with a known allergy * Patients treated with metformin * Patients with severe hepatic impairment defined as a TP spontaneously below 50% * Patients with a history of dysthyroidism * Patient with active neoplasia other than skin cancer * Degradation recent (not older than 3 months) in renal function defined as the deterioration of GFR over 25%. * Estimated GFR less than 15 mL/min/1, 73m2 * Pregnant or lactating * Subjects under the protection of justice

Design outcomes

Primary

Measure	Time frame	Description
Patient with a predictive performance range -30% to +30%	day 0	for each estimator :predictive performance calculated by \[(DFG estimé\* - DFG mesuré par iohexol\\)/DFG mesuré par iohexol\]X100

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026