Pupillary Response After Glaucoma Medication

Effect of Topical Anti-glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02522039

Acronym

pupil

Enrollment

Registered

2015-08-13

Start date

2014-05-31

Completion date

2014-11-30

Last updated

2015-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Effect (Glaucoma Drugs)

Brief summary

Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.

Interventions

DRUGLatanoprost

1 drop of latanoprost was given to study eye after washout period of 1 week between drugs

DRUGTimolol

1 drop of timolol was given to study eye after washout period of 1 week between drugs

DRUGDorzolamide

1 drop of dorzolamide was given to study eye after washout period of 1 week between drugs

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects

Exclusion criteria

* ophthalmological diseases * systemic disease * smoking * refractive error \>= 6 diopters

Design outcomes

Primary

Measure	Time frame	Description
pupillary constriction measured as the post-illimination pupillay response (PIPR)	1 day	The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026