Platelets Rich Fibrin, Palatal Donor Tissue
Conditions
Brief summary
Free gingival grafts are important to increase zone of attached gingiva and root coverage. This case series reveals role of platelet-rich fibrin (PRF) as adjunctive therapy in palatal wound healing. The superior healing observed at the PRF membrane sites supports its use in accelerating soft-tissue healing. PRF membrane as a palatal bandage is an efficacious approach to protect the raw wound area of a palatal donor site to reduce healing time and patient discomfort.
Detailed description
Introduction: Free gingival grafts are one of the common treatment modalities used to increase the zone of keratinized tissue (KT) around implants or prior to ridge augmentation and root coverage. The palatal donor sites had many complications as pain, discomfort and healing by secondary intention. Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors fasten the healing and decrease the pain. Materials and methods: Ten patients requiring augmentation of KT participated in this case series. The palatal donor sites of 7 of these patients were covered with PRF membranes with a new suturing technique without palatal stent, the other 3 had palatal stent. Palatal tissue will examined clinically after 3, 7, 10 and 14 days. Considerably very fast healing with 0 pain score was observed during one week in the group with PRF.
Interventions
BIOLOGICALPlatelets Rich Fibrin in healing of palatal donor tissue
Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors as PDGF, IGF, TGF which had a role in hemostasis fasten the healing and decrease the pain.
OTHERPlacebo
the other group is a control group, had no biologic in the palatal wound, only palatal stent
Sponsors
Ain Shams University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Systemic free, Good oral hygiene and insufficient attached gingiva prior to ridge augmentation
Exclusion criteria
* High arched palate, medically compromised
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Assessment by Visual Analog Scale (VAS) | 1 week postoperative | VAS ranged from 0 (no pain ) to 10 (severe pain) |
| Clinical healing of the palate | 2 weeks postoperative | color match, consistency and thickness of palate (Composite measure) |
Outcome results
None listed