Atrophy, Disuse, Insulin Resistance
Conditions
Brief summary
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
Detailed description
In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.
Interventions
OTHERIntermittent feeding pattern
Intermittent feeding
OTHERContinuous feeding pattern
Continuous feeding
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 18.5 and 35 * Recreationally active
Exclusion criteria
* Type 2 diabetes * Performing progressive resistance training in 6 months prior to study * Back/knee/leg problems * Hypertension * Use of certain anticoagulants * All co morbidities interacting with mobility and muscle metabolism of the lower limbs * Blood donation in past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp) | 7 days bedrest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan) | 7 days bedrest | Via single-slice CT scan |
| Change in lean tissue (measured via DEXA scan) | 7 days bedrest | Via DEXA |
Countries
Netherlands
Outcome results
None listed