Hemorrhage
Conditions
Brief summary
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.
Detailed description
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.
Interventions
DEVICEAuto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)
Blood pass through infusion set without external pressure.
DEVICEAuto PC(Acemedical, Goyang-si, Korea) - 150mmHg
Blood pass through infusion set under external pressure (150mmHg)
DEVICEAuto PC(Acemedical, Goyang-si, Korea) - 200mmHg
Blood pass through infusion set under external pressure (200mmHg)
DEVICEAuto PC(Acemedical, Goyang-si, Korea) - 250mmHg
Blood pass through infusion set under external pressure (250mmHg)
DEVICEAuto PC(Acemedical, Goyang-si, Korea) - 300mmHg
Blood pass through infusion set under external pressure (300mmHg)
Sponsors
Hyub Huh
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers, without any underlying disease.
Exclusion criteria
* history of delivery, abortion in past 6 months. * weight : male under 50kg, female under 45kg * heart rate under 50 or over 100 * fever : over 37.5 * blood pressure : over 180/100
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemolysis and alteration of deformability of red blood cell caused by external pressure | 1hour |
Countries
South Korea
Outcome results
None listed