Sports Nutritional Sciences
Conditions
Brief summary
Creatine (methyl-d3) dilution (D3-creatine) is a novel technique for the estimation of muscle mass. The method uses a dose of deuterium-labelled creatine to determine total skeletal muscle mass via estimation of total body creatine pool size.The aim of this study is to compare estimates of total body skeletal muscle mass by D3-creatine dilution method and whole body Magnetic Resonance Imaging (MRI) in an athletic population.
Interventions
DIETARY_SUPPLEMENTD3 Creatine
One dose of D3 Creatine (60mg capsule) given orally on Day 1
DIETARY_SUPPLEMENTCreatine
Participants will consume an individual dosed level of creatine, based on their estimated muscle mass in doses of 0.03, 0.035, 0.04, 0.045 g.kg.Lean mass/day, increasing on a weekly basis. Final dose of 0.05 g.kg.Lean mass/day is then maintained throughout the study.
Sponsors
GlaxoSmithKline
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Trained and competing elite canoe athletes will be recruited, who represent Great Britain Canoeing
Exclusion criteria
* Pregnant and lactating women * Intolerance or hypersensitivity to Creatine supplementation * Athletes with disabilities which affect their total body muscle mass * If creatine was taken in a supplemented form, rather than dietary intake, more regularly than once a week within 6-weeks of assessment commencing * Contraindication to an MRI scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between muscle mass obtained by MRI method and D3-Creatine method | Upto 3 months | MRI scan of the participants will be done at Day 1 and end of study (i.e.Day 90).D3-Creatine capsule will be given orally at Day 1 and urine samples collected at 0-4h and 4-24h every day from Day 1 to Day 4. |
Countries
United Kingdom
Outcome results
None listed