Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02518776

Acronym

ITEMS

Enrollment

Registered

2015-08-10

Start date

2010-06-30

Completion date

Unknown

Last updated

2015-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Brief summary

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. Various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression. The main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in MS patients

Interventions

BEHAVIORALNeuropsychological tests

Neuropsychological tests

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Men and women 30-60 years of age * Definite MS (McDonald criteria revised in 2005) * EDSS \<6 * Sick Shapes: Relapsing multiple sclerosis, Primary progressive multiple sclerosis * All durations evolution * French Mother tongue * Signature of informed consent

Exclusion criteria

* Other neurological conditions, previous psychiatric or developmental diagnosis of MS * Head injury sequelae * Chronic alcohol or drugs Taking * EDSS greater than or equal to 6 * Secondary Progressive Form * Push and / or treatment with corticosteroids within one month * Treatments Amantadine, Modafinil introduced for less than 3 months * Patient Trust * Cognitive Assessment of less than one year (including in particular all or part of the balance sheet proposed in this project) * Any visual motor deficit or incompatible with the award of cognitive tests * For women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the PET scan) * Patient with indications against MRI

Design outcomes

Primary

Measure	Time frame	Description
anterograde episodic memory: 3 scores of emotional ESR	baseline	3 scores of emotional ESR
retrograde episodic memory: 9 scores TEMP emotional	baseline	9 scores TEMP emotional

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026