Hypoxia, Obesity, Obstructive Sleep Apnoea
Conditions
Keywords
obesity, hypoxia, adipose tissue
Brief summary
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
Detailed description
Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.
Interventions
DEVICEContinuous positive airway pressure devices
overnight use of CPAP device
Sponsors
University of Exeter
Royal Devon and Exeter NHS Foundation Trust
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* men with or without obstructive sleep apnoea
Exclusion criteria
* weight loss interventions * steroid use * active smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pO2 in adipose tissue by Clarke type electrode | 4 months | Measurement of pO2 by Clarke type electrode |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood flow in adipose tissue by laser Doppler techniques | 4 months | assessment of tissue blood flow by laser Doppler techniques |
Other
| Measure | Time frame | Description |
|---|---|---|
| adipose tissue gene expression of HIF-1alpha | 4 months | adipose tissue expression of hypoxia related genes |
Countries
United Kingdom
Outcome results
None listed