Healthy Volunteers
Conditions
Keywords
cognitive assessment, neuropsychological assessment, Brain Performance Test, computerized assessment
Brief summary
The purpose of this study is to evaluate the concurrent validity between the Brain Performance Test (BPT) subtests and corresponding conventional in-person neuropsychological assessments (NP).
Detailed description
This will be a multi-site, randomized, counterbalanced, two-period, two-sequence, validation study of the online, unsupervised Brain Performance Test (BPT). Over the course of 14 days, participants will complete two in-clinic visits during which they will complete both the BPT and in-person neuropsychological assessments (NP).
Interventions
OTHERBPT
Brain Performance Test (BPT) computerized cognitive assessment battery developed by Lumos Labs, Inc.
OTHERNP
Conventional in-person Neuropsychological Assessments (NP) Subtests from: * HRB: Halstead-Reitan Battery * MATRICS: Measurement and Treatment Research to Improve Cognition in Schizophrenia * WAIS-IV: Weschler Adult Intelligence Scale - IV
Sponsors
Collaborative Neuroscience Network
Lumos Labs, Inc.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
70 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* Native English speaker * Capable and willing to provide informed consent * Able to use a computer and mouse without assistance * Limited (\< 3 days) or no experience with Lumosity.com * Limited (\< 3 days) or no experience with other cognitive training programs (e.g., FitBrains, CogMed) * Willing to refrain from online cognitive training during the course of the study * No recent (\<1 years) experience with either computer-based or in-person neuropsychological tests (e.g., WAIS-IV, WISC, Halstead-Reitan Battery, MATRICS, CogState, CNS Vital Signs) * Good general health assessed via self-reported online physical questionnaire and medical history questionnaire
Exclusion criteria
* Illiterate or unable to understand written English sufficiently to comprehend study instructions and consent form * Uncorrected visual impairment (beyond that required to qualify for a California Driver's License) that may impact the ability to complete assessments (self-report or determined by the clinician) * Uncorrected auditory impairment that may impact the ability to complete assessments (self-report or determined by the clinician) * Self-reported clinical diagnosis for primary psychiatric or neurological disorder (e.g., schizophrenia, multiple sclerosis, attention deficit hyperactivity disorder, Parkinson's disease, epilepsy) * Self-reported history of concussion or traumatic brain injury, that is considered clinically significant in the opinion of the investigator (e.g. loss of consciousness ≤ 30 minutes) * Self-reported diagnosis of mental retardation or pervasive developmental disorder * Self-reported diagnosis of Mild Cognitive Impairment, Alzheimer's disease, or other dementia * Self-reported history of sustained substance or alcohol abuse or dependence, that is considered clinically significant in the opinion of the investigator (e.g. as defined by DSM-5) * Self-report that subject is currently taking an antipsychotic, antidepressant, anti-anxiety, or a cognitively-enhancing medication (e.g. Ritalin), or in the last 72 hours, narcotics for pain or other medications that may impact cognitive performance (e.g. sleeping medications/aides or cold/allergy medications) * Any other significant medical condition that could impact cognitive performance or result in cognitive impairment in the opinion of the investigator * Score \<28 on the MMSE * Positive urine test for recent substance use on either testing day * Breath Alcohol Content of 0.01% or greater on either testing day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation coefficients (Pearson's r) of scaled scores of BPT subtests compared to scaled scores of their NP correlates at Time 1 | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| Correlation coefficients (Pearson's r and ICC) of raw scores of BPT subtests compared to raw scores of their NP correlates at Time 1 | 1 day |
| Correlation coefficients (Pearson's r and ICC) of BPT composite indices and NP composite indices at Time 1 | 1 day |
| Interclass correlations (ICC) of scaled scores of BPT subtests compared to scaled scores of their NP correlates at Time 1 | 1 day |
| Correlation coefficients (Pearson's r and ICC) of composite indices of BPT and NP at Time 1 and Time 2 as measures of reliability | 2 weeks |
| Correlation coefficients (Pearson's r and ICC) of BPT Grand Index and NP Overall Index at Time 1 and Time 2 as measures of reliability | 2 weeks |
| Correlation coefficients (Pearson's r and ICC) of raw and scaled scores of BPT subtests at Time 1 and Time 2 as measures of test-retest reliability | 2 weeks |
Countries
United States
Outcome results
None listed