Healthy
Conditions
Keywords
volunteers
Brief summary
From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes. This experiment now will complete the data set-up obtained during the MARS500 study on how these respective individuals will re-act to highly physically and emotionally challenging situations during a parabolic flight. This add-on experiment to MARS500 will enable answering to the following questions i) if the stress response systems - when compared for two conditions but in the same individuals - do react uniformly and ii) if those subjects prone to have adequate stress response pattern will show gradually less immune modulation effects. The understanding of the complex interactions of stress and immunity under chronic and acute stress conditions might help to enable adequate health and immune monitoring and might as well suggest suitable countermeasures for the prevention of the unwanted immunological effects during long-term confinement and space missions.
Interventions
OTHERcellular energy metabolism measurements
purines, lactate
OTHERParabolic flight
OTHERneuro-endocrine measurements
psychic stress tests, stress hormones: prolactin, cortisol, endo-cannabinoids
OTHERimmunological measurements
blood cell counts, B2 integrins, cytokines, C-reactive protein
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers (men or women) * Aged from 18 to 65 * Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) * Who accepted to take part in the study * Who have given their written stated consent * Who participated in the MARS500 experiment * Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection.
Exclusion criteria
* Person who took part in a previous biomedical research protocol, of which exclusion period is not terminated * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neuro-endocrine measurements composite | baseline | prolactin, cortisol, endo-cannabinoids |
| immunological measurements composite | baseline | blood cell counts, B2 integrins, cytokines, C-reactive protein |
| cellular energy metabolism measurements composite | baseline | purines, lactate |
Countries
France
Outcome results
None listed