Alterations in Autonomic Cardiovascular Control Induced at Partial G Forces

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02517177

Acronym

AUTOCARD

Enrollment

Registered

2015-08-06

Start date

2011-06-30

Completion date

Unknown

Last updated

2015-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

volunteers

Brief summary

As a direct consequence of exposure to microgravity, astronauts experience a number of physiological changes which can lead to serious medical implications. Most immediate and significant is the headward shift of body fluids and the removal of gravitational loading from bone and muscles, resulting in progressive changes of the cardiovascular and musculoskeletal systems. The cardiovascular systems is subject to rapid changes which has been demonstrated in studies of short term (shuttle) and long term missions to Skylab and MIR. Our main hypothesis is that there is a linear relationship between the gravity level (0G, 0.16G, 0.38G, 1G, 1.8G) and the cardiovascular parameters (heart rate (HR), heart rate variability (HRV), blood pressure and blood pressure variability (BPV) as well the spectral analysis of HRV and BPV.

Interventions

OTHERParabolic flight

OTHERCardiovascular parameters measurements

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy male volunteer * aged from 20 to 35 * affiliated to a Social Security system and, for non-French resident, holding an European Health Insurance Card (EHIC) * who accepts to take part in the study * who has given their written stated consent * who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude .There will be no additional test

Exclusion criteria

* persons who took part in a previous biomedical research protocol, of which exclusion period is not terminated, * persons who take any medication or drugs influencing the autonomic cardiovascular control

Design outcomes

Primary

Measure	Time frame
The autonomic cardiovascular control evaluated with a spectral analysis of HRV and BPV.	baseline
the blood pressure variability (BPV) derived from the continuous blood pressure recording	baseline
The heart rate (HR) and the heart rate variability (HRV) derived from the ECG	baseline
The systolic, diastolic and mean arterial blood pressure (SP, DP, MAP)	baseline

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026