Sublingual Microcirculation Status
Conditions
Brief summary
This is an observational clinical study, patients with systemic diseases will be enrolled according to the inclusion and exclusion criteria. 360 patients will received the examination of sublingual microcirculation by using sidestream dark filed video microscope. The microcirculation data includes total small vessel density, perfused small vessel density, microvascular flow index, and heterogeneity index. The patients will be divided into right groups according to their systemic diseases as follows: group 1 hypertension (60 patients), group 2 diabetes mellitus (60), group 3 hypertension and diabetes mellitus (60), group 4 end stage renal disease with hemodialysis (60), group 5 peripheral arterial occlusive disease (30), group 6 coronary artery disease (30), group 7 liver cirrhosis (30), and group 8 anemia (30).
Interventions
OTHERNo intervention
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged from 20 to 79 years old * BMI ranged from 18.5 to 27 kg/m2 * Presence of one of the condition 1. Diagnosed hypertenison \> 6 months, without other systemic diseases 2. Diagnosed diabetes mellitus \> 6 monthes, without other systemic diseases 3. Diagnosed with both hypertension and diabetes mellitus \> 6 months, without other systemic diseases 4. Diagnosed with end stage renal disease and recevied renal replacement therapy \> 6 months 5. Diagnosed with peripheral arterial occlusive diseases \> 6 months 6. Diagnosed with coronary artery disease \> 6 months 7. Diagnosed with liver cirrhosis \> 6 months 8. Diagnosed with anemia \> 6 months, hemoglobin level \< 10 g/dL
Exclusion criteria
* Diagnosed with sepsis, major tauma, or admission to ICU within one month * Body temperature higher than 37.5 ℃ or lower than 35.5 ℃ * Any on of the following condition 1. Asthma 2. Chronic obstructive pulmonary disease 3. Endocrine diseases 4. Hematological disorders 5. Uncured cancer 6. Chronic uncured infection 7. Other major disease with limited daily activity * Non-native speakers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total small vessel density of sublingual small vessels | Once at enrollment | Total small vessel density will be measured by Microscan and analyzed by AVA 3.0 software |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perfused small vessel density of sublingual small vessels | Once at enrollment | Perfused small vessel density will be measured by Microscan and analyzed by AVA 3.0 software |
Countries
Taiwan
Contacts
Primary ContactYu-Chang Yeh, M.D., Ph.D
Outcome results
None listed