Non-small Cell Lung Cancer
Conditions
Brief summary
Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.
Interventions
PROCEDUREBone marrow aspiration from the iliac crest
DEVICEIllinois bone marrow aspiration neddle
Sponsors
German Cancer Research Center
Heidelberg University
University Hospital Heidelberg
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with histology proven non-small cell lung cancer or a lesion suspicious of non-small cell lung cancer (lung cancer group) * Healthy donors (control group) * written informed consent
Exclusion criteria
* Autoimmune disease * Patients receiving immunomodulatory drugs, e.g. tacrolimus * Prior malignancy * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequencies of tumor-specific T cells | 2 weeks postoperative | % of all T cells |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tumor-specific T cells location determined by Enzyme Linked Immuno Spot Assay (ELISPOT) analysis of peripheral blood and bone marrow samples from the same patient | 2 weeks postoperative | location: peripheral versus bone marrow |
| Long-term survival | 5 years postoperative | OS |
Countries
Germany
Outcome results
None listed