Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure

Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure - a Randomized Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02515604

Enrollment

180

Registered

2015-08-05

Start date

2015-08-31

Completion date

2016-07-31

Last updated

2016-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abortion, Missed

Brief summary

A randomised controlled trial assessing the efficacy of single versus repeated dose of vaginal misoprostol for the treatment of early pregnancy failure.

Interventions

DRUGMisoprostol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Inclusion criteria

* Women with early pregnancy failure, defined as missed abortion or blighted ovum, seeking medical treatment with misoprostol. * Age equal or greater than 18 years * Gestational age less than 12 complete weeks.

Exclusion criteria

* Complete, incomplete, inevitable, or septic abortion. * Hemodynamically unstable patients. * Misoprostol sensitivity or contraindication. * Multifetal pregnancies.

Design outcomes

Primary

Measure	Time frame	Description
Complete abortion (Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.)	Day 8 from first misoprostol dose	Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026