The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

The Effects of Aerobic Exercise Training in Patients With Cardiovascular Diseases Related to Microvascular Endothelium Function, Angiogenesis, Oxidative Stress and Aerobic Capacity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02514564

Enrollment

115

Registered

2015-08-03

Start date

2014-12-01

Completion date

2016-12-01

Last updated

2026-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Brief summary

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Detailed description

Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Interventions

BEHAVIORALExercise

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

BEHAVIORALSedentarism

Participants will remain sedentary.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* sedentarism for at least 6 months; * clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion criteria

* nephropathies; * decompensated cardiovascular diseases; * liver diseases.

Design outcomes

Primary

Measure	Time frame	Description
Changes in Skin microvascular blood flow	Change from baseline in skin microvascular blood flow at 6 months	Measured through a Laser Speckle Contrast Imaging equipment

Secondary

Measure	Time frame	Description
Change in peak oxygen consumption	Change from baseline in peak oxygen consumption at 6 months	Measured at a maximal graded exercise test
Change in weight	Change from baseline in weight at 6 months	Measured with a calibrated digital scale

Countries

Brazil

Contacts

STUDY_DIRECTOREduardo V Tibiriçá, PhD

Instituto Fernandes Figueira

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 28, 2026