C.Surgical Procedure; Cardiac
Conditions
Keywords
autologous platelet rich plasma, deep hypothermic circulatory arrest, transfusion
Brief summary
The purpose of this study is to determine whether autologous platelet rich plasma (APRP)is effective in reducing allogeneic blood transfusions during aortic surgery using deep hypothermic circulatory arrest.
Interventions
DEVICEAutologous Platelet-Rich Plasma Harvest Technique
15 to 20 mL/kg of whole blood is collected before the administration of heparin from a large-bore central venous access,and is separated into red blood cells component and autologous platelet-rich plasma component by an autologous transfusion system(Sorin Group Electa Essential; Sorin Group Italia, Milan, Italy).
Sponsors
Hongwen Ji
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing elective or emergency aortic surgery using deep hypothermic circulatory arrest、 * preoperative platelet counts\>150000000000/L、 * preoperative hematocrit\>33%、 * without recent anticoagulants less than 5 days
Exclusion criteria
* preoperative coagulation disorder * severe renal and liver dysfunction * preoperative hemodynamic instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total perioperative allogenic transfusions of platelet and fresh frozen plasma | on the 7th day postoperatively |
Secondary
| Measure | Time frame |
|---|---|
| postoperative blood loss | on the 7th day postoperatively |
| rate of reexploration for bleeding | on the 7th day postoperatively |
Countries
China
Outcome results
None listed