Penetration and Compartimentation of HIV

Penetration and Compartimentation of HIV in Genital Mucosa

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02513758

Enrollment

200

Registered

2015-08-03

Start date

2002-11-30

Completion date

2014-12-31

Last updated

2016-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV

Keywords

HIV patients, Genital HIV penetration

Brief summary

Genital mucosa is the main way of HIV penetration. Many cells can be involved (epithelial cells, Langerhans cells) and antibodies may also play a critical role. The investigators' study aims to precise the role of each type of cells, the interaction cell-cell and cell-antibodies.

Detailed description

At inclusion, men will have a two blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm and women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions

Interventions

OTHERsample

Men will have blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm Women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults (\> 18 year-old) HIV positive, * HIV-CV\> 1000 cp/ml,

Exclusion criteria

* children

Design outcomes

Primary

Measure	Time frame	Description
Viral tropism of HIV	Inclusion	number of HIV virus in sperm or cervical secretions.

Secondary

Measure	Time frame	Description
Genetic polymorphism for HIV strains	Inclusion	With a sequencing method, it is possible to classify the different strains in groups, according to their polymorphism.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026