Optic Nerve Sheath Diameter for Prediction of Outcome After Cardiac Arrest

The Optic Nerve Sheath Diameter for Prediction of Outcome After Cardiac Arrest: a Pilot Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02513628

Acronym

ONSD-CA

Enrollment

Registered

2015-07-31

Start date

2011-11-30

Completion date

2014-01-31

Last updated

2015-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

Cardiac arrest, neuroprognostication, optic nerve sheath diameter, outcome, ultrasonography

Brief summary

Early prognostication in resuscitated cardiac arrest (CA) patients, within the first day after admission in the intensive care unit (ICU), remains difficult. Optic nerve sheath diameter (ONSD) measurement could predict increased intracranial pressure. Preliminary works showed that ONSD measurement could be used to predict outcome in post-CA patients. The aim of this study was to assess the ability of bedside ONSD ultrasonographic measurement to predict survival and Cerebral Performance Category (CPC) score at hospital discharge in post-cardiac arrest patients treated with therapeutic hypothermia (TH).

Detailed description

Prospective observational study including all consecutive successfully resuscitated and TH-treated CA patients without traumatic or neurological etiology of CA in two French ICUs. ONSD measurements were performed on day 1, 2, and 3 after return of spontaneous circulation (ONSD1,2,3 respectively). The primary outcome is survival at hospital discharge (with an average follow-up of 3 month until ICU admission).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Unconscious (Glasgow Coma Scale ≤6) * ≥18 years old * Admitted in ICU after successful resuscitation from CA * Treated with TH targeted to 33°C

Exclusion criteria

* unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability) * Traumatic or neurological origin of CA * Previous cerebrovascular disease * Facial trauma affecting the orbits and/or eyeballs * Previous history of ocular pathology such as exophthalmia, glaucoma or cataract.

Design outcomes

Primary

Measure	Time frame	Description
In-hospital mortality	3 months	participants will be followed for the duration of hospital stay, an expected average of 3 months.

Outcome results