Pain Insensitivity, Congenital
Conditions
Keywords
Lumbar epidural anaesthesia
Brief summary
This study compares the clinical efficacy of newer local anaesthetic drugs Levobupivacaine and Ropivacaine with Bupivacaine in lumbar epidural anaesthesia for hip surgeries.
Detailed description
Some of the most common day care surgeries are hip surgeries, in which local anaesthetic agents can be used via epidural route for both intra-op and post-op analgesia. Among the drugs used nowadays are Lignocaine, Bupivacaine, Levobupivacaine and Ropivacaine.However Bupivacaine usage is not free from side effects. The claimed benefits of both Levobupivacaine and Ropivacaine are reduced cardiac toxicity on overdose and more specific effects on sensory rather than motor nerve fibres. Ropivacaine, an analog of Mepivacaine, is one of the long acting amide anaesthetic agent similar to Bupivacaine in chemical structure and anaesthetic function. It is a first enantiomer-specific compound, which has a reduced risk of cardio toxicity, neuro toxicity and rapid recovery of motor function. Levobupivacaine is the pure S (-)-enantiomer of Bupivacaine, and in recent year has emerged as a safer alternative for regional anaesthesia than its racemic parent.
Interventions
DRUGBupivacaine
Local anesthetic
DRUGLevobupivacaine
Local anesthetic
DRUGRopivacaine
Local anesthetic
Sponsors
Government Medical College, Haldwani
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA Grade I and II patients of either sex * Age 18-60 years * Undergoing various hip surgeries under lumbar epidural anesthesia
Exclusion criteria
* Refusal for epidural * ASA-III&IV * Head injury * Psychiatric disease * Known allergic to test drugs * Major systemic disease * Any analgesia with in past 24 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Onset of sensory block | 30 minutes | Time to achieve sensory block up to tenth thoracic dermatome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time for 2 segment regression of sensory block | 90 minutes | Time for regression of sensory block 2 segments lower than maximum blocked dermatome |
| Time to achieve maximum motor block | 45 minutes | Time to achieve motor block of modified Bromage score |
Countries
India
Outcome results
None listed