Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin

Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin and Titanium Platelet Rich Fibrin: A Randomized Clinical Comparative Study

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02512952

Enrollment

Registered

2015-07-31

Start date

2014-06-30

Completion date

2015-03-31

Last updated

2015-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

Periodontal regeneration, Growth factors

Brief summary

Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the treatment of intrabony defects (IBDs). Materials and methods: Study was conducted on subjects reporting to the Department of Periodontics, The Oxford Dental College and Hospital, Bangalore. 38 subjects with 90 periodontal IBDs of moderate to severe periodontitis were selected and assigned to OFD alone (group I) or OFD with Autologous PRF (group II) or OFD with TPRF (group III). In each subject, a minimum number of two sextants were present with probing pocket depths (PPD) ≥5mm in at least three teeth.

Interventions

PROCEDUREOpen flap debridement (OFD)

Oral prophylaxis followed by Open flap debridement (OFD)

PROCEDUREOFD with Platelet rich fibrin (PRF)

Oral prophylaxis followed by Open flap debridement (OFD) with Platelet rich fibrin (PRF) placement into the bone defect

PROCEDUREOFD with Titanium Platelet rich fibrin (TPRF)

Oral prophylaxis followed by Open flap debridement (OFD) with Titanium Platelet rich fibrin (TPRF) placement into the bone defect

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 55 Years

Healthy volunteers

Inclusion criteria

* presence of minimum 20 permanent teeth * age group 20-55 years * radiographic evidence of periodontal IBDs * probing pocket depth (PPD) \>5mm in minimum two sextants in at least three teeth * clinical attachment (CA) loss of ≥ 3mm.

Exclusion criteria

* Systemically compromised subjects * those on medications (corticosteroids/ bisphosphonate therapy) that may interfere with wound healing * grade III tooth mobility * smokers and alcoholic subjects * pregnant and lactating mothers * subjects who underwent periodontal treatment within a period of 1 year.

Design outcomes

Primary

Measure	Time frame
defect depth reduction (DDR)	Change from baseline to 9 months
change in clinical attachment level (CAL)	Change from baseline to 9 months

Secondary

Measure	Time frame
change in probing pocket depths (PPD)	Change from baseline to 9 months
change in plaque index (PI)	Change from baseline to 9 months

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026