The Expression of the Ionotropic Glutamate Receptors in Colon of IBS

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02512146

Enrollment

Registered

2015-07-30

Start date

2015-06-30

Completion date

2016-06-30

Last updated

2015-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Keywords

IBS, Ionotropic glutamate receptors

Brief summary

The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Detailed description

Ionotropic glutamate receptors participate in pain in nervous system. In this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms. Participants may futher study the mechanism using cell experiment.

Interventions

PROCEDUREcolonoscopy

Patients will undergo colonoscopy and participants will get biopsies from the colon.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

Exclusion criteria

Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
the expression of the ionotropic glutamate receptors	4 months	Participants will examine the expression level of ionotropic glutamate receptors using quantitative real-time RT-PCR and western blot ,examine the distribution using immunohistochemy.
the relationship between the ionotropic glutamate receptors and IBS symptom	6 months	Symptoms will be assessed though the severity of abdominal pain or discomfort and seizure frequency.Participants will evaluate the relationship between the expression level or the distribution of ionotropic glutamate receptors and IBS symptom. If there is a link between them, participants will study the underlying molecular mechanisms.

Countries

China

Contacts

Primary Contactxiuli zuo, PHD

xiulizuo@gmail.com15588818685

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026